Study: CBN Reverses Age-Related Cognitive Decline
The Science Behind TruCBN™: Reversing Cognitive Decline
A landmark study has produced compelling evidence that TruCBN™ can reverse cognitive decline associated with aging.
The research, published in Redox Biology, marks the first demonstration that TruCBN™ can actively restore brain function in a robust aging model, establishing a new frontier for cannabinoid-based cognitive support.
“While our cell culture studies suggested that CBN might be effective in vivo, it was really exciting to actually see these beneficial effects in aging mice which indicates that further studies with CBN are warranted”
-Dr. Pamela Maher, Study Author & Research Professor, Salk Institute
Key Study Findings:
Improved Cognitive Function
Sex-Specific Metabolic Effects
Neuroprotection
Synaptic Restoration:

CBN Preserves Mitochondria & Protects Neurons from Age-Related Stress
In an earlier foundational study published in Free Radical Biology & Medicine, researchers demonstrated that CBN:
- Prevents neuron death under conditions of oxidative stress
- Maintains healthy mitochondrial shape and energy output
- Acts through a novel mechanism, independent of CB1/CB2 pathways
These findings laid the groundwork for deeper exploration into CBN's role in neurodegeneration, culminating in the recent SAMP8 in vivo results.
What This Means for the Future of Brain Health
By targeting mitochondrial dysfunction, oxidative stress, and synaptic loss, TruCBN™ opens the door to novel interventions for age-related neurodegenerative diseases — including Alzheimer’s, Parkinson’s, and related conditions.
These preclinical results position TruCBN™ as a promising ingredient for both prevention and therapeutic support, in the context of neurodegenerative disease and age-related cognitive decline.
.webp)


Leading the Way in Cannabinoid Research
At FloraWorks, we are committed to innovation through collaboration. By working closely with leading academic institutions and research organizations, we aim to accelerate advancements in well-being through combined expertise and shared goals.
Together, we are pioneering research into the endocannabinoid system and exploring the vast potential of cannabinoids and cannabinoid-inspired compounds to improve the lives of millions.
Join us on this journey of discovery and innovation.

TruCBN™ in the news
Explore how TruCBN™ is redefining sleep wellness with clinically validated research, making headlines as the trusted, scientifically-backed choice for better rest.